John C Reilly is an American actor. John C Reilly is one of several actors whose careers were launched by Brian De Palma. To date, John C Reilly has appeared in more than fifty film productions, including three separate films in 2002, each of which was nominated for the Academy Award for Best Picture.

John C Reilly was nominated for an Academy Award for Best Supporting Actor for his role in Chicago and a Grammy Award for the song Walk Hard, which he wrote and performed in.

John C Reilly, the fifth of six children, was born to an Irish American father and a Lithuanian mother and raised in Chicago. He was raised as a Catholic and graduated from Brother Rice High School.

John C Reilly graduated from DePaul University in Chicago. While discussing life in Chicago on the set of the film Step Brothers, he and co-star Richard Jenkins realized that when he was four, the two had met when Jenkins worked for his father.